The crash happened near the NC-42 interchange just before 9 a.m.
According to the North Carolina State Highway Patrol, a vehicle occupied by three people was traveling west on I-40 near exit 312 when it lost control, crossed the median and traveled into the path of a tractor-trailer going the other direction.
The tractor-trailer crashed head-on into the car.
One person inside the car died in the crash. The other two were seriously injured.
The driver of the tractor-trailer was not injured.
In addition to that crash, three tractor-trailers that were headed eastbound collided as they approached the original crash scene.
It's unclear why the car lost control and crossed the median.
Johnston County Wreck Blocking the Road: Involved Four 18-Wheeler I 40 EB near Hwy 42 - Exit 312 Extrication in progress— Raleigh Traffic (@TotalTrafficRDU) August 16, 2019