On Saturday, he transformed a Massachusetts vaccination clinic into a temporary concert hall, in a moment that residents called a symbolic representation of "the light at the end of the tunnel."
Ma, 65, received his second shot, alongside his wife, Jill Hornor, at Berkshire Community College in Pittsfield, Massachusetts, on Saturday.
When he arrived at the clinic carrying his cello, the nurse who gave him his vaccine asked whether he would be willing to use his 15-minute observation period to offer a short concert to those in the waiting area.
The famed cellist was "delighted," Richard Hall of the Berkshire COVID-19 Vaccine Collaborative, told ABC News, as he wanted to "give something back to the community."
Donning a cap and T-shirt, Ma sat masked and socially distanced from others as he played an array of classical selections, including Franz Schubert's "Ave Maria" and Johann Sebastian Bach's Cello Suite No. 1 in G Major, Prélude.
"I think that everyone there was touched just listening to him play," Hall said.
Berkshire County, Massachusetts, is known for its arts community, and after a year in which the arts have been largely silenced, "it was quite special to just listen to him play the cello," Hall said.
A year ago, when the pandemic began, Ma began an online series titled "#SongsOfComfort," in an effort to offer solace and ease anxieties "in the face of fear and isolation."
"In these days of anxiety, I wanted to find a way to continue to share some of the music that gives me comfort," Ma wrote on Twitter, exactly a year before he received his second shot.
In these days of anxiety, I wanted to find a way to continue to share some of the music that gives me comfort. The first of my #SongsOfComfort: Dvořák – "Going Home”— Yo-Yo Ma (@YoYo_Ma) March 13, 2020
Stay safe. pic.twitter.com/S28w6OlXiZ
His social media project, which started as short, self-shot videos filmed from home, soon expanded into a worldwide effort that has reached more than 18 million people, according Ma's website.
In December, Ma and pianist Kathryn Stott released an album titled "Songs of Comfort and Hope."
"Songs are little time capsules of emotions: they can contain long-lost dreams and desires, and feelings of great spirit, optimism, and unity," Ma and Stott wrote in announcing the album. "Songs bring a sense of community, identity, and purpose, crossing boundaries and binding us together in thanks, consolation, and encouragement."