Police said a man was taken to the hospital with serious injuries.
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The highway was down to one lane as police investigated.
Police have not said what led to the shooting.
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There have been no arrests.
The ABC11 I-Team said it found there have been at least three shootings on interstates in Durham since 2018 -- all three along I-85.
Raleigh reports at least five incidents of gun violence on interstates and highways during that timeframe.
Three of those shootings left three people dead.
Across the country, shootings on or near interstates and highways increased from 540 in 2019 to 846 in 2021, a 57% increase.
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