It happened around 9:45 p.m. on Enterprise Street at South Roxboro Street, just south of downtown Durham.
Authorities said 46-year-old Aaron Christopher Ryle of Durham was pronounced dead at the scene.
The No. 7 GoDurham bus was making a left turn onto Enterprise Street when the deadly collision happened.
It's not yet clear whether the victim was in a crosswalk when he was attempting to cross Roxboro Street.
The driver of the bus, and a male passenger on board, were not injured.
No charges have been filed, but the accident remains under investigation.
In a release, the Go Durham team said it was "saddened to learn that the incident resulted in a fatality and our thoughts and prayers are with those impacted."
Durham bus strikes, kills pedestrian