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Flight 1674 from Orlando to Philadelphia landed safely at Raleigh-Durham with 230 passengers and seven crew members.
A total of eight people - including a flight attendant - complained of illness. Three of them were taken for treatment, Wake EMS told ABC11.
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"In this kind of situation, anyone requesting a medical evaluation receives one," said Richard Oliver, a Frontier spokesman. One flight attendant requested to be taken to the hospital."
"Safety and security of our crew and guests is our number one priority," the spokesperson said.
The plane taxied to the gate under its own power.
"A new aircraft is being sent to continue the flight," Oliver said. "It will be departing Orlando shortly to ferry to RDU to pick up passengers."