Crews worked for hours to clear the crash scene after the truck flipped in the median around 3 a.m.
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The median cables along I-40 kept the box truck from crashing into the westbound lanes.
The driver was not seriously hurt. It is unclear what caused the crash.
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All eastbound lanes had to be closed between Bus 70 at Exit 306 and the Clayton Bypass at Exit 312. One lane was closed in the westbound direction.