It happened around 5:30 p.m. Thursday in a shopping center in Rockville, Maryland.
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The Montgomery County Fire and Rescue Service responded to the scene.
Fire officials said the driver was smoking a cigarette and then started to use hand sanitizer.
The sanitizer ignited and set the whole car on fire.
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The man was taken to the hospital with minor burns, firefighters said. His injuries are said to be non-life-threatening.
Officials said "using hand sanitizer and smoking a cigarette is a bad combo in unventilated areas like a car."
The vehicle was a total loss.