Cary police said they received a call to the 1500 block of Regency Parkway just after 7:40 p.m., where an attendant at the hotel told police that someone fired a gun inside a hotel room.
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When police arrived, they found 39-year-old Kerry Keaton dead in the hotel parking lot from an apparent self-inflicted gunshot wound.
Police also found 44-year-old Shanta Pollard Shermeker who suffered from life-threatening injuries from a gunshot wound and was immediately taken to WakeMed Raleigh.
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Cary police said Keaton and Shermeker were in a long-term romantic relationship.
Police believe the shooting to be contained and are investigating the incident.