During his opening monologue, wearing a red, Chicago Teachers Union sweatshirt, the rapper sent messages of support to the striking teachers.
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"To the teachers in Chicago, I know you guys are on strike right now, I just want you to know I fully support you," the rapper said.
RELATED: CTU says $38 million of CPS budget stands between contract agreement as strike enters 11th day
He also created some very funny raps about the city's nickname. Watch the video above to see more.
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Chance first hosted the late-night comedy show back in 2017.