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Clemons, a junior guard from Raleigh, made 10 of 15 field-goal attempts, including 4-of-8 3s, and had five assists. The 5-foot-9 junior has 1,526 career points in 67 games. He moved into 11th place on Campbell's all-time scoring list, 5th in the Division I era (since '77-78).
It was Campbell's largest margin of victory in Gore Arena, which opened in 2008, and the fourth-highest point total in the program's history.
Clemons scored seven points, and Shane Whitfield added all of his six points, during a 19-6 run to open the game and the Camels never trailed. Clemons hit a 3-pointer to push the lead to 20 points midway through the first half and Campbell (1-1) led 49-22 at the break.
Druw Rollins had 13 points and Micah Banks scored 12 for Columbia International, a member of the National Christian College Athletic Association.
Campbell hit 13 3-pointers, shot 61 percent from the field and scored 33 points off 22 Rams turnovers.
Clemons followed Friday's season-opening 39-point effort with his 41st 20-plus point outing in just 68 games. On Monday night, he made 10-of-15 shots, 4-of-8 from 3-point range, dealt 5 assists and had 2 steals.
Freshman Brooks Cluxton came off the bench to grab a game-high 10 rebounds in 19 minutes. Cory Gensler, Jordan Whitfield, and Mogga Lado added 8 points apiece for CU.
Campbell returns to action Saturday in a 7 p.m. start at UNC Wilmington.