"Right now - there's no cure for ALS. As a former athlete, it's like in baseball, you're facing a pitcher that's never lost. You have to keep grinding every day," Combs said.
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So that's what he does. Two years ago, Combs was just months into his diagnosis. Since then, little by little, the disease has dug in.
"Day-to-day normal activities you take for granted, eating and getting dressed, are getting tougher for me," he said.
Giving up his Wolfpack Club responsibilities hit hard.
"One of your jobs that I always loved was going on the road and meeting people and forming relationships," Combs said.
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While his body has weakened, Combs' spirit remains steadfast. Friday night's Hope Gala for Project ALS at the Umstead is his biggest annual venture and will raise well in excess of a million dollars for ALS research.
Combs called it "a night of hope where friends and loved ones get together."
His support system is strong; his family of course and he's very thankful for the friendship and support of folks like Dave Doeren and Elliott Avent.
"The drive to raise awareness and raise funds is kind of what keeps me going," Combs said.