Highway Patrol said a van was traveling the wrong way on U.S. Highway 117 near Brogden in the northbound lane when the driver struck a pick-up truck and another car.
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At least one person was pronounced dead at the scene and another was taken to a local hospital.
U.S. Highway 117 was closed in both directions at the scene.
No names have yet to be released, as the investigation ins ongoing. Please check back for updates.