The crash happened on northbound Creedmoor Road (NC-50) near Strickland Road around 4:20 p.m. All northbound lanes were shut down until after 6 p.m.
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A state trooper said a 2003 Nissan Altima going south on Creedmoor Road attempted to make a left on Southampton Drive but failed to yield the right of way and turned in front of a 2012 Ford Mustang, which was going north on Creedmoor Road.
The driver of the Altima, Cecelia Raynor, 47, of Raleigh and a rear-seat passenger, 33-year-old Peter Norden, also of Raleigh, were taken to WakeMed with serious but non-life-threatening injuries.
The driver of the Mustang, Michael Prince, 49, of Raleigh was taken to Rex Hospital with non-life-threatening injuries.
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Raynor was charged with an unsafe movement violation.
Troopers said no alcohol was involved, and all three people were wearing their seatbelts.
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