Deputies responding to a call about a victim in need found a woman in apparent distress running in the road on Alice Miller Court, near Efland-Cheeks Community Center.
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The woman said she knew her assailants. She was taken to a hospital for treatment.
Orange County deputies found the suspects in a car nearby. They arrested Deandre Edwards, 29, and Derrick Tate, 33, both of Mebane.
Both are charged with first-degree forcible rape, first-degree forcible sexual offense, and kidnapping.
Edwards is being held at the Orange County Detention Center on a $480,000 secured bond, and Tate is being held on a $610,000 bond.
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A sheriff's office spokesperson said additional charges are possible as the investigation continues.
Anyone with information about this incident is asked to contact the Orange County Sheriff's Office at (919) 245-2925.