The robbery happened just before 11 a.m. on Wednesday at First Horizon Bank in the 2000 block of NC 54 Highway.
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Officers were told a man had robbed the bank. Video surveillance showed the suspect entering and exiting the business.
Durham Police looking for bank robbery suspect
The man left through the front door and fled in a newer model silver or gray GMC Acadia with a partial North Carolina registration of HJC-16.
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He was last seen heading north on NC 55 Highway.
Anyone with any information is asked to please contact Investigator S. Ellison at (919) 560-4440 extension 29550 or CrimeStoppers at (919) 683-1200. CrimeStoppers pays cash rewards for information leading to arrests in felony cases and callers never have to identify themselves.