The crash happened around 5 p.m. on Holloway Street near Interstate 885 in Durham.
North Carolina State Highway Patrol said a trooper was chasing after the wrong-way driver when the crash happened.
At least three vehicles were involved. Highway Patrol said none of the injuries sustained appear to be life-threatening at this time.
The wrong-way driver has been arrested. Investigators believe impairment was a factor in the crash.
Eyewitness Christian Todd was stopped at the light at Holloway Street and I-885 when he saw a car crash head-on into several vehicles. He said he saw a trooper chasing after a white car when it entered the intersection.
"I didn't realize he was chasing a suspect at first until I saw the suspect run head-on into several vehicles," Todd said. "The suspect looking around panicked. Frantic. Considering what his next move was as the cop came out of the car... yelling at him, get out of the vehicle."
Todd said as he pulled away he saw a family from the other vehicles holding each other while a child was crying.
"It didn't even register at first, just sitting there looking at this cop, this trooper going full speed and I didn't even see he was chasing someone because I was focused on his lights," he said. "You see the impact, the smoke, you could hear the audible gasps from the people around me, my window was open"