It happened just after 5:30 a.m. between Fayetteville Street and Alston Avenue.
The ramp at Fayetteville Street was closed for more than hour after a crash between a commercial truck that was carrying about 10,000 pounds of cargo, and a car.
Images from the scene showed a silver sedan with serious damage.
Police say there were two minor injuries reported.
It is unclear what caused the crash.
Both southbound lanes of NC-147 were reopened around 7 a.m.