The incident happened just after 9 a.m. Monday in the 5800 block of Farrington Road.
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Officials said a series of roof trusses collapsed on a new three-story apartment building which is under construction.
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The injured worker - who had not been identified - needed to be immobilized before being brought to the ground.
Durham Fire Department crews were on scene to treat the man.
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He was packaged in a stokes basket, lowered him to the ground with the help of a ladder truck, and transported to UNC Health Care.
The extent of his injuries is unknown; authorities have not commented on what caused the trusses to collapse.