15-501 North was shut down at Tower Boulevard. The shooting happened around 8:30 p.m.
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Police found a man shot inside a car. He was pronounced dead at the scene.
Police said the victim was driving northbound on 15-501 when shots were fired from another vehicle also traveling northbound.
Durham police are actively investigating.
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The roadway was closed for several hours, but has since reopened.
Anyone with information is asked to contact Investigator M. Adams at (919) 560-4440 ext. 29546 or CrimeStoppers at 919-683-1200. CrimeStoppers pays cash rewards for information leading to arrests in felony cases and callers never have to identify themselves.