It happened shortly before 1 p.m. in the 200 block of Broadway Street,
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Police said officers found one man with a gunshot wound in the 800 block of North Mangum Street. A second man was taken to a hospital in a private vehicle.
DPD said both victims suffered life-threatening injuries.
One man told ABC11 that he heard gunshots and thought the sound was from a nearby construction project. A woman in the area said she didn't hear anything, but she is tired of how often crime happens in the neighborhood.
"It's very tiring because it happens at your doorstep or workplace like this place," said Jasmine Hudson. "Everybody including here is just tired. Tired of all this gun violence happening."
Investigators said this appears to be an isolated incident. They continued to comb through evidence through the late afternoon and early evening.
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Officers arrested Sequan Malone, 22, of Durham. He has been charged with assault with a deadly weapon with intent to kill. Malone is currently being held in the Durham County Jail with no bond.
The names of the victims have not yet been released.
Anyone with any information in this case is asked to call Investigator D. Cramer at (919) 560-4440 ext. 29284 or CrimeStoppers at (919) 683-1200. CrimeStoppers pays cash rewards for information leading to arrests in felony cases and callers never have to identify themselves.
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2 men seriously injured in shooting near downtown Durham