The victim has been identified as Timothy Devon Fuller, 22, of Durham.
Fuller died on Thursday and the case is now being investigated as a homicide.
No charges have been filed at this time.
Stay on top of breaking news - download the ABC11 News App
Police said two people were seen leaving S. Elm Street in a dark sedan after the shooting there.
The shooting happened just minutes after another shooting just after 11 p.m. Tuesday in the 500 block of Liberty Street. A man was shot, police said, but that victim is expected to recover.
ORIGINAL STORY: 2 HURT IN SEPARATE SHOOTINGS NEAR DOWNTOWN DURHAM
Anyone with information is asked to call Investigator Hines at (919) 560-4440, ext. 29322 or CrimeStoppers at (919) 683-1200. CrimeStoppers pays cash rewards for information leading to arrests in felony cases and callers never have to identify themselves.
Report a Typo