The call came in just after 9 a.m., according to police.
Upon arrival, officers found 31-year-old David Kelly dead inside of the Quality Inn in the 3700 block of Hillsborough Road.
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Officials said the homicide happened during an altercation.
The investigation is ongoing.
Police are working to determine if a crash on Hillsborough Road and 9th Street is related to the incident.
Police working to find out if crash on Hillsborough is related to stabbing at Quality Inn
This is a developing story. Check back for updates.
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Anyone with information is asked to call Investigator J. Mitchell at (919) 560-4440, ext. 29335 or CrimeStoppers at (919) 683-1200. CrimeStoppers pays cash rewards for information leading to arrests in felony cases and callers never have to identify themselves.