Officers responded to a call around 4:42 p.m.
According to police, one driver was turning left from Calvary Drive onto northbound Louisburg Road and was struck in the intersection by another driver traveling southbound on Louisburg.
Both drivers sustained injuries and were transported to Wake Med, according to police.
One of the drivers, 63-year-old Kimberly Devere Orawiec later died at the hospital.
The other driver, 34-year-old Dionicio Cristobal Rodgriguez Domingo, has been charged with failure to stop at a stop light and misdemeanor death by motor vehicle.