Fire officials said the flames broke out just after 8:45 Sunday night in a home near Pecan Drive.
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When firefighters arrived, bystanders told crews someone may still be inside of the residence.
Officials entered the home and located a person inside.
They were removed, treated by firefighters, and transported to Cape Fear Valley Hospital in critical condition.
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Upon arrival, the person had succumbed to their injuries and was pronounced dead.
Their identity has not yet been released.
A full fire investigation is being conducted by Fayetteville Fire and Emergency Management; authorities believe the fire was accidental.