According to Fayetteville police, it happened on Santa Fe Drive at the All American Freeway around 3:30 p.m.
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Officials say the woman, who was driving the motorcycle, struck a car. When police arrived, she was pronounced dead at the scene.
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Police have shut down Santa Fe Drive near the wreck and are urging drivers to avoid the area if possible.
This is a developing story. Please check back for more details.