The shooting happened on Charlie Drive in Fayetteville around 5 a.m.
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A spokesperson for the sheriff's office said deputies were called for a report of a home invasion.
Previously, it was believed the resident shot four people during a break-in.
However, the sheriff's office now says the shooting was believed to be drug-related and not random.
Authorities say a man walked into the home and shot four others.
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Two of them have died from their injuries, according to the sheriff's office. One is at a local hospital in critical condition.
The fourth sustained non life-threatening injuries.
The homicide unit is investigating.
Anyone with information is asked to contact Senior Sergeant R. Quick at (910) 677-5503.