Chopper 11 flew over the home on South Bend Drive, which is located in southern Durham County off Fayetteville Road south of The Streets at Southpoint.
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Firefighters were still dousing the home with water when Chopper 11 arrived.
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The fire had already burned through the house's roof and destroyed most if not all of the home.
Durham Fire Department confirmed one firefighter had to be taken to the hospital for injuries sustained during a collapse inside the home. The firefighter has not been identified, but he is expected to be OK.