Fayetteville Police said two cars, a black Kia sedan carrying an adult and two children, and a gray Hyundai sedan with an adult and a teenager crashed head-on along Gillis Hill Road around 4 p.m.
Gillis Hill Road is closed from Raeford Road to Stoney Point Road. Authorities are asking drivers to avoid the area.
ABC11 crews at the scene said both drivers and their passengers were taken to the hospital with non-life threatening injuries.
There's no timetable for when the road will reopen.