Coats Grove Fire and Rescue, Buies Creek EMS, Erwin Fire and Rescue and Harnett County EMS responded.
Firefighters said the crash was a rollover with pin-in.
Four people from two vehicles were taken to WakeMed with varying traumas, according to ABC11 breaking news crews on the scene.
North Carolina State Highway Patrol is investigating.
The intersection was closed as the wreck investigation continued.