North Roxboro Road was shut down about 4:30 p.m., the Durham Fire Department said after a spill at the intersection with Infinity Road.
Approximately 330 gallons of sodium hypochlorite (pool chlorine) spilled from a tank and entered a storm drain.
N. Roxboro Road reopened shortly after 6:30 p.m. after firefighters worked the hazmat scene.
No one was injured.