The crash happened near Exit 270 (US 15/501) shortly after 4:30 p.m. The road reopened just before 8 p.m.
A car traveling north on 15/501 went down the embankment after crashing through a guardrail, the Highway Patrol said. It then flipped and came to rest in the lanes of I-40.
The person in that vehicle died, the Highway Patrol said.
The crash remains under investigation.