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Police said a 22-year-old woman was shot at least once in the lower part of her body.
The victim was taken to WakeMed with what appear to be non-life-threatening injuries.
The incident happened just before 8 p.m.
Police think the incident happened when the woman accidentally cut off another driver, who became irate.
The victim had a passenger in the car. That person did not appear to be injured.
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I-440 Eastbound has reopened.
Anyone with information that might assist this investigation is asked to call Raleigh CrimeStoppers at (919) 834-HELP or visit raleighcrimestoppers.org for text and email reporting options. CrimeStoppers pays cash rewards for anonymous tips that help solve cases.