It happened in a construction zone where traffic was down to one lane in each direction with a concrete barrier between.
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Troopers said a trailer was going south on I-85 when it cut left to avoid another car and hit a barrier.
The impact caused the barrier to break and spill into the northbound lane, causing another vechile to turn over.
Troopers said the driver of the trailer was uninjured; however, the other driver sustained minor injuries.
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The highway reopened just after 5:30 p.m.
Authorities said the driver of the trailer will be cited for driving too closely.