North Carolina State Highway Patrol troopers on the scene said one tractor-trailer rear-ended the other, and both caught fire after the crash.
ABC11 crews on the scene saw firefighters working to battle what was left of the flames and surveying the damage to the vehicles.
The road closed around 2:30 a.m., but reopened just before 8 a.m.
The driver that hit the other tractor-trailer was taken to the hospital with non-life-threatening injuries.
We continue to learn more about this ongoing story. Please check back for updates.