All lanes of I-95 North were closed near Exit 75, Jonesboro Road, near Dunn as fire crews worked the scene.
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All the lanes reopened shortly before 7 p.m., the NCDOT said.
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An ABC11 crew at the scene said earlier that traffic was backed up for at least 10 miles.
Even though the lanes are open, congestion may remain in the area for a while.
Drivers are advised to take Exit 73 to US-421 South, Turn right onto US-421 South. Follow US-421 South to NC-242 North, Turn left onto NC-242 North, and continue on NC-242 North to reaccess I-95.
Tractor trailer fire closes northbound lanes of I-95