The crashes happened about 8 p.m. in both the northbound and southbound lanes near mile marker 87.
Two 18-wheelers were involved. A breaking news crew at the scene saw one in the median and one on the shoulder.
The Four Oaks Fire Department said in all, 13 people were injured and four of those were taken to a hospital. There was no immediate word on their conditions.
All lanes of I-95 have since reopened.