The crash happened near exit 127 between Rocky Mount and Wilson around 9 a.m.
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North Carolina Highway Patrol troopers said a mini-van tried to merge onto the highway and collided with a tanker truck.
The driver of the van, 25-year-old Patrick McLaughlin, was killed. A pregnant woman and a 5-year-old child in the van were hurt.
The family dog - a Rottweiler called "Blitz" - hasn't been seen since the crash.
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Anyone who finds him is asked to contact the Nash County Animal Shelter at (252) 459-9855.
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