Video from Chopper 11 showed two tractor-trailers and a pickup truck involved in the crash.
The crash happened just before 3 p.m.
North Carolina State Highway Patrol said a tractor-trailer was exited off I-40 onto I-95. According to NCSHP, the driver had not seen traffic had come to a stop.
The driver then locked the brakes, went off the road, lost control and crossed all lanes to the left, striking another tractor-trailer and red pickup truck.
Officials said two drivers were transported to local hospitals with minor injuries.
Lanes reopened around 4:30 p.m.