Reports said the man, identified as Curtis Roeman Mangum, 32, appeared to exhibit signs of "medical distress" after he and another man were taken into custody on drug-related charges.
Warrants were obtained against the two men for possession with intent to sell and deliver marijuana; possession with intent to sell and deliver cocaine; and possession of drug paraphernalia.
The other suspect, Dextro James White Jr., 40, is charged with carrying a concealed weapon and with keeping and maintaining a vehicle for the purposes of keeping and selling cocaine and marijuana.
The incident happened shortly after 10 p.m. after officers conducted a traffic stop in the 400 block of Rose Lane.
As is standard procedure for in-custody deaths, the Chief of Police will send a Five-Day Report to the City Manager within five business days.