Traffic was backed up for over a mile along westbound I-40 and southbound I-85 after a tractor trailer rear-ended another tractor trailer near mile marker 155.
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One of the truck drivers was taken to Alamance Regional Medical Center with minor injuries.
According to authorities, a tractor trailer carrying "medical material" caused the collision just before 3 a.m. when it slammed into the back of a tractor trailer carrying steel that stopped for traffic ahead.
Debris was strewn about, and one of the big rigs straddled all four southbound lanes of the highway.
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Two minor crashes occurred east of the original one due to the heavy traffic.
All four lanes of the highway were reopened just after 7 a.m.
The driver of the second truck was charged with failure to reduce speed, and reckless driving.