Police said the victim, Chadiya Jones, died as a result of her injuries.
The suspect, 21-year-old Markease Morgan, has been charged with first-degree murder.
Authorities said the suspect and victim knew each other.
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Officers were called to the hotel at 1491 US 70 in Garner after reports of a shooting.
When police arrived, they found a victim with a gunshot wound in a room on the motel's third floor.
Guests staying at the motel told ABC11 a car was seen leaving the property shortly after the shooting.
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This investigation is ongoing.