The accident happened in the 64 hundred block of Devils Racetrack Road near Strickland's Crossroads.
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Troopers said that a man driving a white car failed to stop at a stop sign and was hit by a gold GMC pickup. Both of the vehicles ended up in the front yard of a home.
The man driving the car was seriously injured and the passenger died at the scene. The person driving the truck only had minor injuries.
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Troopers are still investigating and they suspect that alcohol may have been a factor.
The names of the people involved have not been released.