Deputies said it happened just before midnight in the 1100 block of Mount Carmel Church Road when they received a call from a man who said he had been shot along with a woman.
Upon arrival, both victims were found in a car with gunshot wounds.
Lacoria Cox, 20, of Pikeville died at the hospital.
The 23-year-old male victim was taken to Vidant Hospital in Greenville with life-threatening-injuries.
The investigation is ongoing.