Police said it happened Wednesday about 1 p.m. when a man with a handgun entered Carter Bank at 205 S. Bickett Blvd. and demanded money from a teller.
He fled on foot with an undisclosed amount of money.
The suspect is described as a black man with a dark complexion, about 6 feet tall with a slim build and facial hair.
He was wearing a dark-colored hooded jacket, dark pants, and dark shoes.
Anyone with information is asked to contact the Louisburg Police Department at (919) 496-4175.