Authorities said it happened shortly after 1 p.m. in the 500 block of Dupree Street.
Officers found Michael Askins, 43, inside the home suffering from gunshot wounds. The Askins was pronounced dead at the scene.
The investigation revealed the shooting does not appear to be random.
Anyone with information is asked to call Investigator Bongarten at (919) 560-4440, ext. 29529 or CrimeStoppers at (919) 683-1200. CrimeStoppers pays cash rewards for information leading to arrests in felony cases and callers never have to identify themselves.
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