The Chapel Hill Police Department said they haven't been seen since last Wednesday.
Police believe Tyliyah Baldwin, 14, and Kaaliyah Alston,15, are somewhere in Durham.
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Tyliyah is 5' 6", about 130 pounds, and has a nose piercing.
Kaaliyah is 5' 6" and weighs about 140-145 pounds.
If you know anything, please call Chapel Hill Police Department at (919) 968-2760 or 911.