It happened a little before noon at the entrance to the Lowe's Foods, Garner Police said.
According to police, a 2005 Lincoln headed west on Timber Drive turned left into the path of the motorcycle to enter the parking lot.
The motorcyclist, Robert Joseph Chiappetta, of Garner, died at the hospital.
The driver and passenger of the Lincoln were not injured.
The incident remains under investigation and no charges have been filed.