Deputies responded to a call for service involving a man in the early morning hours of Saturday, said Chief Deputy Brandon Medina.
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During the encounter, shots were fired and the man, identified as 28-year-old Jonathan Ramirez, died at the scene.
The Nash County Sheriff's Office did not say whether the man was armed or not.
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Law enforcement is still on the scene and the State Bureau of Investigations has been asked to investigate the incident.
"A citizen of our community has lost his life, a family is mourning, and our law enforcement agency is deeply saddened as a result of what has happened. Please join us as our thoughts and prayers go out to all those affected by this tragic incident," said Chief Deputy Brandon Medina.