Boone was a sparkplug in the paint for the Cowboys (4-1) after halftime, throwing down three dunks and blunting N.C State rallies. Walker added 16 points, including a pair of 3-pointers and six of six free throws, and Tyreek Smith scored 10.
Dereon Seabron led the Wolfpack (3-1) with 19 points and 10 rebounds while Jericole Hellems added 15 of his 18 in the second half, including 10 of 10 from the line. Cam Hayes added a season-high 16 points.
Boone scored eight points early in the second half as the Cowboys put together a 10-3 run to build a 14-point lead, 50-36 with 10:32 remaining.
N.C. State whittled the lead to two, 68-66, on a 9-2 run in the final 1:04 before Williams and Walker secured the Cowboys win at the line.
The Cowboys ended the first half on a 12-0 run, capped by a nifty bounce pass from Isaac Likekele to Bryce Thompson for a breakaway dunk. The assist, though his lone dish in the game, was Likekele's 357th in his career, boosting him into eighth place on Oklahoma State's all-time list.
The Wolfpack got little production off the bench with only Jaylon Gibson (5 points) getting into the scoring column. Freshman Terquavion Smith missed all five of his shots from the floor.
The Cowboys outrebounded the Pack 44-39, which led most of the second half but lost the lead by halftime.
N.C. State will look to bounce back Sunday at home against Texas Southern.