Cary firefighters were called to the scene around 3:45 p.m.
A large tree fell on the corner of the home on Champion Drive, later in the evening, another part of the tree split and crashed through another neighbor's home.
After crushing the home, the tree landed in the front yard.
Neighbor Stephanie Peters says she was just finishing up work when she heard the tree collapse on her neighbors home.
"I heard something outside so I looked out the window, saw a white cloud of smoke and by the time I got outside, it settled down and you saw the tree had come down in our neighbor's yard," Peters said.
A large chunk of the wall was ripped off, leaving what appeared to be a bedroom exposed to the elements.
In Durham, a tree was struck by lightning, causing a branch to fall in the yard of a home on Raynor Street.